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Software Engineer, Applied AI

OpenEvidence
Posted onFeb 13, 2026
LocationSan Francisco, California, United States (On-site)
Employment typeFull-time

Role

As an Applied AI Software Engineer working at OpenEvidence, you will build end-to-end systems grounded in a strong intuition for how to leverage modern models as components of thoughtful, intentional products.

We hire for exceptional builders, not narrow lanes, and engineers work across products and projects, owning work wherever they can create the most impact.

About Us

OpenEvidence is the most widely used medical AI platform in the world.

In just over a year, our usage has grown to >40% of US clinicians via product-led word of mouth adoption. We are a $12B company with a 30-person engineering team from MIT, Harvard, and Stanford. We believe world-changing products come from a small group of exceptional, autonomous builders, organized along focused objectives and empowered to take individual ownership and run fast. We are growing our team to seize a once-in-a-lifetime opportunity to define the default platform for medical AI.

If you are a world-class engineer or scientist looking to define the bleeding edge and deliver concrete outcomes that impact hundreds of millions of lives, we want to talk.

Culture

We believe work should be engaged with at a world-class level. Building 0->1 and scaling 1->1000 are professional sports, and uncompromising excellence is the bar. We believe building technologies that haven't existed is only possible with end-to-end ownership. Important things are accomplished when an individual decides to accomplish them.

Who are you?

If you are looking to complete tickets 9-5 that someone else assigns, this job is not for you. If you are looking to write papers, this job is not for you. If you are looking to lean in and get your hands dirty, bruised, and bloody, making something from nothing, personally impact hundreds of millions of lives, and drive ten figures of revenue, this job might be for you.

The ideal candidate is a brilliant builder. They are smart, ambitious, scrappy, autonomous, precise, motivated, hard-working, and low-ego. Does that sound rare? It is rare, we have only found 30 of them, and we would like to find more.

Location

All full-time roles on our engineering team are in-person 5 days a week in SF.

OpenEvidence is the leading AI-powered medical information platform used by over 40% of U.S. physicians to make evidence-based clinical decisions at the point of care.

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