OP

Software Engineer, Data Infrastructure

OpenEvidence
Posted onFeb 25, 2026
LocationSan Francisco, California, United States | Miami, Florida, United States (On-site)
Employment typeFull-time

Role

As a Data Infrastructure Software Engineer working at OpenEvidence, you will build end-to-end systems powering critical product and research workflows. Your work will focus on performance, scalability, and accuracy, granting you full autonomy over the infrastructure that helps doctors navigate complex clinical decisions in real-time.

We hire exceptional builders, not in narrow lanes. Engineers work across products and projects, owning work wherever they can create the most impact.

About Us

OpenEvidence is the most widely used medical AI platform in the world.

In just over a year, our usage has grown to >40% of US clinicians via product-led word of mouth adoption. We are a $12B company with a 30-person engineering team from MIT, Harvard, and Stanford. We believe world-changing products come from a small group of exceptional, autonomous builders, organized along focused objectives and empowered to take individual ownership and run fast. We are growing our team to seize a once-in-a-lifetime opportunity to define the default platform for medical AI.

If you are a world-class engineer or scientist looking to define the bleeding edge and deliver concrete outcomes that impact hundreds of millions of lives, we want to talk.

Culture

We believe work should be engaged with at a world-class level. Building 0->1 and scaling 1->1000 are professional sports, and uncompromising excellence is the bar. We believe building technologies that haven't existed is only possible with end-to-end ownership. Important things are accomplished when an individual decides to accomplish them.

Who are you?

If you are looking to complete tickets 9-5, this job is not for you. If you are looking to write papers, this job is not for you. If you are looking to lean in and get your hands dirty, bruised, and bloody, making something from nothing, personally impacting hundreds of millions of lives, and driving ten figures of revenue, this job might be for you.

The ideal candidate is a brilliant builder. They are smart, ambitious, scrappy, autonomous, precise, motivated, hard-working, and low-ego. Does that sound rare? It is rare, we have only found 30 of them, and we would like to find more.

Location

All full-time roles on our engineering team are in-person 5 days a week in SF or Miami.

OpenEvidence is the leading AI-powered medical information platform used by over 40% of U.S. physicians to make evidence-based clinical decisions at the point of care.

Similar jobs

You might also be interested in...

SE2w

Software Engineer, Internal Tools

Sesame

San Francisco, California, United States (On-site)

$175k – $280k Yearly

HA1w

Software Engineer - Backend

HappyRobot

San Francisco, California, United States (On-site)

$140k – $220k Yearly

TM5d

Software Engineer, Data Infrastructure

Thinking Machines Lab

San Francisco, California, United States (On-site)

$350k – $475k Yearly

OP1w

Software Engineer, Data Acquisition

OpenAI

San Francisco, California, United States (On-site)

$325k – $405k Yearly

XA5d

Software Engineer - Data Platform

xAI

Palo Alto, California, United States (On-site)

$180k – $440k Yearly